Thursday, June 14, 2007

ACCUTANE DRUG INTERACTION

What drug(s) may interact with ACCUTANE (isotretinoin)?

  • alcohol
  • benzoyl peroxide, salicylic acid, or other drying medicines used for acne
  • corticosteroids (example: prednisone)
  • medicines for seizures
  • orlistat
  • other drugs that make you more sensitive to the sun such as sulfa drugs
  • progestin-only birth control hormones (examples: 'Minipills' like Aygestin®, Micronor®, Nor-QD® or injectable/implantable products such as Depo-Provera® or Norplant®)
  • tetracycline antibiotics (examples: doxycycline, tetracycline)
  • vitamins and other supplements containing vitamin A
  • warfarin
© Ramzaj
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Monday, May 21, 2007

7 Rules On Care Of A Problem Skin

By Ramzaj

Councils about care of a problem skin. How to choose cosmetics for skin purification at acnes.

The correct care of a skin it is more narrow half of victory over spots and acnes. The care of a skin will allow to intercept new rashes, to reduce treatment terms, will reduce requirement for medicines and cosmetic procedures.

1. To begin with try not to squeeze out spots. The occluded comedoes and inflammatory devices of an eruption cannot neither be squeezed out, nor to dissect. It follow-up damages a skin, enhances an inflammation, promotes an infection contamination and can cause scars. If you cannot overcome desire that revert to the expert.

2. Wash the face twice a day, but be not overzealous with washing, spots do not arise from a dirty skin. Too frequent washing can provoke an inflammation. Instead of ordinary soap it is better to use special, and also refining skins or gels (routinely names contain words cleansing, cleanser or directly specify in use at fat / to a problem skin, predilection to acnes). Wash simply arms, easy locomotions, with warm water, after washing put a towel, instead of triturate it a skin. Yield a skin to dry up 10-15 minutes before drawing of any agents against spots.

3. If at you "oily" type of a hair, wash them every day with suitable shampoo. Do not allow a hair to occlude a face skin, forehead, temples. Avoid cosmetics fat and containing an oil for a hair.

4. Use such cosmetics and agents of hygiene which suit a fat skin. Normally they contain an inscription «non-comedogenic», i.e. do not promote formation of comedoes, an occlusion of dermal pores. Same concerns a make-up and protective sunburn creams. At use of many aboriginal drugs from spots wetting agents (moisturizer, it is ordinary this milk) will be necessary for you. They can possess sun-protection properties (SPF).

5. Spare a skin from an abudant solar irradiating. Do not use sun decks. That the sun itself will cure spots - a myth, instead of a reality. Sunburn only masks spots. Tendency promptly to receive sunburn quite often conducts to skin photodamage, and it threatens with a carcinoma cutaneum, a melanoma. Some agents of treatment of acnes increase sensitivity of a skin to an ultraviolet.

6. Avoid abrasion of a skin in those places where routinely there are spots. This council concerns not only clothes and dressings, but also the playing sports bound to use of protective inventory (top sections, overlays, etc.). The open skin should not adjoin to them.

7. For daily care of a problem face skin, inclined to acnes, it is released much only. For example, the scraps, helping to peel high layer of a skin and to discover pores (it is possible to use 1-2 times a week if there is no inflammation). Try also refining lotions and napkins - 2 times a day. Choose soft, not the revellents approaching your skin. Some agents on a leaving can not be combined with peeling drugs for treatment of acnes.

If you already apply any outside agent to treatment of acnes, yield it to work. Skin purification make not after, and before drawing of a medical drug. Choose for all it suitable time.

The correct care of a skin will bring to you a lot of advantage. But do not count that only care of a skin will relieve you of spots. Such it is possible not always and not to all.

© Ramzaj
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Sunday, May 20, 2007

Hormones And Skin

By Ramzaj

Man's sexual hormones and skin. Testosterone, other androgens also that on them influences.

Formation of dermal grease is boosted by man's sexual hormones - androgens. The most active androgens - testosterone, 5-testosterone (dihydrotestosterone, DHT) and 5-androstendiol. Despite of the name, man's sexual hormones is and at women. Androgens are produced by sexual glands: at men in testicles, at women - in ovaries. Both female, and man's sexual glands are checked by hormones of a pituitary body - a member which is being a brain.








testosterone








dihydrotestosterone (DHT)








5-androstendiol

In a skin activity of androgens strengthens some ferments (an androgen - reductases I of type, 5-alpha-reductase). These ferments transmute less active androgens into more active: testosterone and DHT (5-testosterone). Crates of a follicle have receptors of androgens and can accept signals from them.

Changes in a level of the hormones, descending during puberty, explain occurrence of spots in teenagers.

Activity of sebaceous glands can variate and at some diseases of endocrine system: a pituitary body, paranephroses, or man's and female sexual glands. The quantity of dermal grease on a skin thus increases or contracts.

The reinforced formation of dermal grease, seborrhea and acnes can educe not only from pinch of the common level of sexual hormones in a blood. The most part of testosterone in a blood is bound by special protein SHBG (the globulin binding sexual hormones). Deficiency SHBG result ins to strengthening of the free testosterone which is joined to receptors in sebaceous glands. Activity of ferment 5-alpha-reductases can be increased at some people. As a result at these people on sebaceous glands react more active androgens. Sensitivity of a skin and sebaceous glands to androgens at some people also appears higher.

Female sexual hormones - the estrogens used in hormonal contraception, reduce formation of dermal grease. The same effect drugs - can yield antiandrogens.

Purpose of drugs of testosterone to boys up to period of puberty (or progesterones with androgenic properties) boosts formation of dermal grease ice and promotes development of acnes.

And still, androgens - not the single hormones influencing operation of sebaceous glands. Similar influence is rendered with a growth hormone and an insulinoid growth factor.

Some states related to the hormonal status of the person, can worsen a state of a skin. It is a syndrome of polycystic ovaries (at women), Cushing syndrome (from the long-term treatment by steroid hormones). Also failure of ferments which control formation of sexual hormones: for example, sterol-hydroxylases, that descends very seldom, and also depression and the strong psychologic stress.

© Ramzaj
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Monday, May 14, 2007

Why There Are Scars?

By Ramzaj
Scars after acnes as a consequence of an inflammation and fracture of tissues. Phylums of scars after pimples.

Scars are formed in those places where there is the strong damage and fracture of tissues. In a skin it is the copulative tissue surrounding hair follicles, and sometimes - hypodermic cellulose.

Scars arise during response of tissues to damage, process of an adhesion of wounds. When something collapses, formed "hole" is closed up by those materials of which the copulative tissue is constructed. First of all, it is a collagen. Process of an adhesion and a cicatrization of each damage lasts about one month.

"Repair" of tissues descends in terminating stage of an inflammation. At an inflammation of a tissue are always damaged. When it is enough fracture greater, or process of an adhesion is broken, the former structure of a tissue sometimes is not recovered. The scar is formed on its place.

At acnes are formed two phylums of scars - atrophic and hypertrophic. The arrest of development means a deficiency of propagation, and a hypertrophy - excess. The strong or feeble ability of a copulative tissue form a collagen can to be a specific feature of the person. On different fields of a skin formation of a cicatrical tissue goes with different intensity, it depends on blood supply of the yielded area. For example, on cheeks occurrence of scars more possibly, than on temples.

At atrophic scars formation of a collagen goes with small intensity, it suffices only on repair of walls of "hole". Such holes are the flaws of the skin which have arisen after fracture of a follicle and a copulative tissue surrounding it, and even hypodermic cellulose. Fracture can be greater - and scars can be deep and wide. It is characteristic for heavy shapes of disease.

Besides attempts to squeeze out and dissect spots invoke additional damage of tissues - so, and occurrence of scars. Thus in a wound the infection contamination that else complicates an adhesion can be brought.

At hypertrophic scars formation of a collagen goes more strongly, than it is required, and the scar rises above a surface of a skin. The expressed hypertrophic scars-keloids it is possible to expect at the people predisposed to such response at a genetical level. They have inborn features of synthesis of a collagen and formation of a scar goes more longly - for example, at many people with a dark skin.

Most the poor in scars - that they do not peter. They remain for a long time, and without treatment for ever. Scars cannot dissolve. Any treatment of scars includes their physical removal - bodily or stratums.

During an aging people lose a dermal collagen, approximately on 1 % a year, since 40 years. Therefore at older persons some scars become more appreciable, and others - are less appreciable.

The main thing that it is necessary to remember about scars are that at acnes they arise only as a consequence of an inflammation. The one who can prevent the strong inflammation, can avoid and occurrences of scars.

The main thing to make it, yet late.

© Ramzaj
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